LSD1/HDAC6-IN-1 is an orally active dual inhibitor of lysine specific demethylase 1(LSD1)/Histone deacetylase 6 (HDAC6), with anti-tumor activity. LSD1/HDAC6-IN-1 can be used for the research of multiple myeloma (MM).

Product information

Molecular Weight: 815.10

Formula: C50H66N6O4

Chemical Name: N-hydroxy-4-{3-[4-({[(1R,2S)-2-phenylcyclopropyl]amino}methyl)piperidin-1-yl]propyl}benzamide; N-hydroxy-4-{3-[4-({[(1S,2R)-2-phenylcyclopropyl]amino}methyl)piperidin-1-yl]propyl}benzamide

Smiles: ONC(=O)C1C=CC(CCCN2CCC(CN[C@@H]3C[C@H]3C3C=CC=CC=3)CC2)=CC=1.ONC(=O)C1C=CC(CCCN2CCC(CN[C@H]3C[C@@H]3C3C=CC=CC=3)CC2)=CC=1

InChiKey: LRLKEHSULHZRIQ-IHCSCSDWSA-N

InChi: InChI=1S/2C25H33N3O2/c2*29-25(27-30)22-10-8-19(9-11-22)5-4-14-28-15-12-20(13-16-28)18-26-24-17-23(24)21-6-2-1-3-7-21/h2*1-3,6-11,20,23-24,26,30H,4-5,12-18H2,(H,27,29)/t2*23-,24+/m10/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

LSD1/HDAC6-IN-1 shows superior potency in multiple MM lines.

In Vivo:

LSD1/HDAC6-IN-1 is efficacy in the MM.1S xenograft model.

Products are for research use only. Not for human use.