LyP-1 is a cyclic 9‐amino‐acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells.

Product information

CAS Number: 454487-07-1

Molecular Weight: 976.14

Formula: C36H65N17O11S2

Chemical Name: 2-[(2S,5S,8S,11S,14S,20R,23R)-5-(4-aminobutyl)-8,14-bis({3-[(diaminomethylidene)amino]propyl})-11-[(1R)-1-hydroxyethyl]-3,6,9,12,15,18,21,24,27-nonaoxo-20,23-bis(sulfanylmethyl)-1,4,7,10,13,16,19,22,25-nonaazacycloheptacosan-2-yl]acetamide

Smiles: C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC1=O

InChiKey: KMBIQFHFIJTDAK-SLQNPQMPSA-N

InChi: InChI=1S/C36H65N17O11S2/c1-17(54)27-34(64)51-18(7-4-10-43-35(39)40)28(58)45-14-26(57)48-23(16-66)33(63)52-22(15-65)29(59)46-13-25(56)47-21(12-24(38)55)32(62)50-19(6-2-3-9-37)30(60)49-20(31(61)53-27)8-5-11-44-36(41)42/h17-23,27,54,65-66H,2-16,37H2,1H3,(H2,38,55)(H,45,58)(H,46,59)(H,47,56)(H,48,57)(H,49,60)(H,50,62)(H,51,64)(H,52,63)(H,53,61)(H4,39,40,43)(H4,41,42,44)/t17-,18+,19+,20+,21+,22+,23+,27+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

LyP-1 (8 weeks) shows a remarkable reduction in plaque formation and plaque occupation rates in the LyP-1-treated group. In addition, a higher apoptotic rate in macrophages released from hypoxic plaques is observed after the treatment of LyP-1when compared to control peptide. The LyP-1 peptide is labeled with a near-infrared fluorophore (Cy5.5) for optical imaging. At days 3, 7, 14 and 21 after inoculation with 4T1 cells, tumor-bearing BALB/C mice is injected Cy5.5-LyP-1 (0.8 nmol) through the middle phalanges of the upper extremities of the tumor-bearing mice. The fluorescence intensities were 0.024, 0.038, 0.048 and 0.106×106 photon/cm2/sec respectively at days 3, 7, 14 and 21 after tumor cell inoculation, which are 1.02, 1.63, 2.04, and 4.52-fold higher than in the contralateral LNs. Cy5.5-LyP-1 staining in LNs co-localized with LYVE-1, suggesting lymphatics-specific binding of LyP-1 peptide.

Products are for research use only. Not for human use.